BMDL

Bioinspired Materials Design Lab

Journal

Macroencapsulation Device with Anti-inflammatory Membrane Modification Enhances Long-Term Viability and Function of Transplanted β Cells
Year
2024
Author
MinJi Park, Hyun Lee, Yerim Jang, Min Ji Kim, Younghak Cho, Sophie S. Liu, JungEun Lee, Surim Shim, Hyun-Do Jung*, Hyejeong Seong, Kisuk Yang
Publication date
2024/12/25
Journal
ACS Applied Materials & Interfaces
ISSN
1944-8244
Vol
16(51)
Page
70218–70230
File
park-et-al-2024-macroencapsulation-device-with-anti-inflammatory-membrane-modification-enhances-long-term-viability-and.pdf (9.7M) 8회 다운로드 DATE : 2024-12-27 12:14:47
Treating type 1 diabetes (T1D) through β-cell macroencapsulation is a promising long-term solution, but it faces challenges such as immune-mediated fibrosis on the capsule surface, which impairs cell functionality and compromises longevity and effectiveness. This study presents an approach for including an anti-inflammatory molecule on the macroencapsulation device (MED) using initiated chemical vapor deposition for the surface modification of poly(tetrafluoroethylene) (PTFE) membranes. The surface-modified MEDs significantly reduced fibrosis, improved β-cell viability and functionality, and promoted M2 macrophage polarization, which is associated with anti-inflammatory effects. This MED displayed improved glycemic control in a streptozotocin-induced diabetic mouse model for 45 days. The findings underscore the potential of surface-modified MEDs for improving T1D management by mitigating inflammation and enhancing the therapeutic efficacy of β-cell encapsulation.