BMDL

Bioinspired Materials Design Lab

Journal

A flexible and multimodal biosensing patch integrated with microfluidics for chronic wound monitoring
Year
2024
Author
Md Selim Reza, Md Sharifuzzaman, Zahidul Islam, Md Assaduzaman, YeYoung Lee, Dongyun Kim, M.Robiul Islam, Hyeong Seok Kang, HongSeok Kim, Dae Heum Kim, Hyun-Do Jung*, Jae Yeong Park
Publication date
2024/12/1
Journal
Chemical Engineering Journal
ISSN
1385-8947
Vol
501
Page
157673
File
1-s2.0-S1385894724091642-main.pdf (12.8M) 4회 다운로드 DATE : 2024-11-17 22:13:44
A wearable biosensing patch for the monitoring of physiochemical parameters related to chronic wounds presents a promising approach to personalized wound management. Despite considerable advances in multimodal biosensing patches for wound care, fully integrated patches with microfluidic channels to monitor multiple parameters are still a challenge. Herein, a flexible multimodal biosensing patch integrated with microfluidic channels is newly proposed. The patch comprises a polar array of seven biosensors fabricated on a flexible polyethylene terephthalate substrate. An SU-8-based microfluidic channel with arrowhead micropatterns is formed directly on the sensor via the lithography process. The integration of the microfluidic channels results in a fluid collection efficiency that is increased 6.5 times higher owing to the fluidic diode effect of the micropattern. The sensing platform is functionalized with a gold nanowire-incorporated reduced graphene oxide composite to fabricate an electrochemical biosensor array. This array is used in detecting three metabolites (glucose, lactate, and uric acid), two ions (Na+ and K+), pH, and temperature. The sensor responses are calibrated using a pH- and temperature-compensation algorithm to accurately quantify the analyte concentration and evaluate multi-sensing capability in the rat wound model. Its unique design and multiplexed sensing capacities offer significant advancements in nonhealing wound monitoring.