This cover visualizes an advanced biodegradable vascular stent engineered through 3D printing and Janus nanoengineering. Inspired by dynamic vascular environments, the design integrates silica-based nanocomposites for mechanical strength and bioactivity. A dual-functional surface promotes endothelial regeneration while simultaneously suppressing smooth muscle overgrowth and thrombosis via controlled drug release. This synergistic platform highlights a transformative strategy for restoring vascular function with precision and biological harmony. More details can be found in the Research Article by Hyun-Do Jung, Jung-Hoon Park, and co-workers (DOI: 10.1002/advs.202523965).