Diabetic foot ulcers (DFUs) remain trapped in a selfreinforcing loop of inflammation, oxidative stress, and impaired perfusion, and recurrence is common despite debridement, offloading, antibiotics, and conventional dressings. Wang et al. frame DFU as an “inflammation-ischemia” vicious cycle and argue that symptom-centric strategies often fail to reset the wound microenvironment. This challenge is amplified in military and disaster situations, where wound care must be delivered with limited infrastructure, constrained followup, and heightened contamination risk. Prolonged Field Care guidance emphasizes practical wound protection, infection control, and approaches that remain functional when resources are austere. These realities have accelerated interest in therapies that are i) field-deployable, ii) manufacturable at scale, and iii) robust against hostile wound milieus